This March 1940 cover of Thrilling Mystery by Rudolph Berlarski is about as mad science as it gets. The ISFDB entry for this issue is here. I found this version of the cover at Pulp Covers.
Pulp Parade #96: This may hurt a little
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This pulp cover shows the origin story for Tiny Pet Women, which I celebrated on my Tumblr. This needle is too large for any valid purpose, he could never hit a vein with her wiggling around in the air. I call this a Baffling Wierd Novelet.
No one ever said these mad science villains were paragons of rationality.