Big scary apes of some kind have a long history in tales of mad science, especially around pretty women, who are ever at risk of being menaced by them, carried off by them, or even transformed into them.
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Someone tried getting that sort of mad science excitement into this image, but seems to have missed the mark. This is a publicity still from a 1942 B picture, The Strange Case of Dr. RX. Our rather unimpressed looking damsel is Anne Gwynne (1918-2003) and presumably the man in the gorilla suit is Ray “Crash” Corrigan (1902-1976). Don’t you wish you had a name as cool as “Ray ‘Crash’ Corrigan?” Of course you do.
This image a reblog from a 3 January 2013 post at Infernal Wonders. Its original source is the tumblr Damsel Lover.
Not mad science as such, but…
https://youtu.be/jlqLVAtXsFA